Antibacterial Activity of Hylomecon hylomeconoides Against Methicillin-Resistant Staphylococcus aureus

作者：Choi Jang Gi; Kang Ok Hwa; Chae Hee Sung; Obiang Obounou Brice; Lee Young Seob; Oh You Chang; Kim Min San; Shin Dong Won; Kim Jeong Ah; Kim Young Ho; Kwon Dong Yeul^*

来源：Applied Biochemistry and Biotechnology, 2010, 160(8): 2467-2474.

DOI：10.1007/s12010-009-8698-5

• Antibacterial
• MRSA
• Hylomecon hylomeconoides
• EtOH extract 6-Methoxydihydrosanguinarine

Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH(2)Cl(2), EtOAc, and H(2)O) were investigated against MRSA. The most active extract (CH(2)Cl(2)) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 mu g/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 mu g/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

• 出版日期2010-4