alpha-Cyclodextrin/aminobenzoic acid binding in salt solutions at different pH: Dependence on guest structure

作者：Romanova Anastasia; Chibunova Ekaterina; Kumeev Roman; Fedorov Maxim; Terekhova Irina^*

来源：International Journal of Biological Macromolecules, 2013, 57: 255-258.

DOI：10.1016/j.ijbiomac.2013.03.032

• Cyclodextrin aminobenzoic acids
• Guest-host binding
• Inclusion complex formation
• Salt effect
• Hydration

Influence of Na+ and K+ cations on alpha-cyclodextrin guest host complex formation with isomeric aminobenzoic acids was examined at different pH and temperature of 298.15 K by H-1 NMR and calorimetry methods. More pronounced influence of Na+ on inclusion complex formation of alpha-CD with aminobenzoic acid anions compare to the effects of Na+ on alpha-CD complex formation with zwitterionic aminobenzoic acid molecules was revealed. For the first time, the dependence of salt effects on the structure, ionization and the hydration state of the guest molecule was demonstrated and analysed on the basis of the obtained thermodynamic parameters of complex formation and calculated free energy of hydration of different ionized forms of aminobenzoic acids.

• 出版日期2013-6