Second-Line Antiretroviral Treatment Successfully Resuppresses Drug-Resistant HIV-1 After First-Line Failure: Prospective Cohort in Sub-Saharan Africa

作者：Sigaloff Kim C E^*; Hamers Raph L; Wallis Carole L; Kityo Cissy; Siwale Margaret; Ive Prudence; Botes Mariette E; Mandaliya Kishor; Wellington Maureen; Osibogun Akin; Stevens Wendy S; van Vugt Michele; de Wit Tobias F Rinke

来源：Journal of Infectious Diseases, 2012, 205(11): 1739-1744.

DOI：10.1093/infdis/jis261

Little is known about the effect of human immunodeficiency virus type 1 (HIV-1) resistance mutations present at time of regimen switch on the response to second-line antiretroviral therapy in Africa. In adults who switched to boosted protease inhibitor-based regimens after first-line failure, HIV-RNA and genotypic resistance testing was performed at switch and after 12 months. Factors associated with treatment failure were assessed using logistic regression. Of 243 participants, 53% were predicted to receive partially active second-line regimens due to drug resistance. The risk of treatment failure was, however, not increased in these participants. In this African cohort, boosted protease inhibitors successfully resuppressed drug-resistant HIV after first-line failure.

• 出版日期2012-6-1