Antioxidant effect of the Egyptian freshwater Procambarus clarkii extract in rat liver and erythrocytes

作者：Fahmy Sohair R^*; Hamdi Salwa A H

来源：African Journal of Pharmacy and Pharmacology, 2011, 5(6): 776-785.

DOI：10.5897/ajpp11.232

• Procambarus clarkii
• freshwater shrimp
• liver
• CCl4
• erythrocytes
• oxidative stress

The present study aims to evaluate the curative activity of freshwater crustacean extract (FCE) from freshwater crayfish Procambarus clarkii and silymarin on oxidative stress induced by carbon tetrachloride (CCl4) in rat liver and erythrocytes. The degree of treatment in this activity has been measured by using biochemical parameters such as serum aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP) and total protein as well as malondialdehyde (MDA), glutathione reduced (GSH), glutathione-S-transferase (GST) and catalase (CAT) in liver tissue and erytheocyte hemolysate. The FCE and silymarin produced significant antihepatotoxic effect by decreasing the activity of serum enzymes and MDA level, and increasing the serum total protein, GSH levels and the activities of GST and CAT in liver and erytheocyte hemolysate. From these results, it was suggested that FCE could ameliorate the liver and erythrocytes injuries perhaps, by its antioxidative effect, hence eliminating the deleterious effect of toxic metabolites from CCl4.

• 出版日期2011-6