Amygdala - and serum - neurotrophic factor levels depend on rearing condition in male rats

作者：Babri S; Mohaddes G; Mosaferi B^*

来源：Journal of Developmental Origins of Health and Disease, 2018, 9(4): 377-380.

DOI：10.1017/S2040174418000144

• amygdala
• brain-derived neurotrophic factor
• early life experiences
• environmental enrichment
• psychiatric disorders

Early life experiences could determine brain and behavioral development. Neurotrophic factors are likely to mediate the effects of the experience on brain structures and function. Brain-derived neurotrophic factor (BDNF) plays a central role in psychiatric disorders. To investigate the effects of early rearing condition on the amygdala - and serum - BDNF levels, we reared male Wistar rats from weaning (postnatal days 21) to adulthood (postnatal days 119) in three different rearing conditions: (1) enriched, (2) standard and (3) isolated. We found that long-term post-weaning environmental enrichment leads to lower amygdala - and serum - BDNF levels as well as lower brain weights. Grouped rearing in standard laboratory cages enhanced body weight. Thus, early rearing condition might play a crucial role in adult healthiness by predetermining individual BDNF profiles.

• 出版日期2018-8