A mild and efficient CAN mediated oxidation of Morita-Baylis-Hillman adducts of 5-methyl-N-alkylisatin to 5-formyl-N-alkylisatin

作者：Shanmugam Ponnusamy^*; Vaithiyanathan Vadivel; Selvakumar Kodirajan

来源：Tetrahedron Letters, 2008, 49(13): 2119-2123.

DOI：10.1016/j.tetlet.2008.01.119

• CAN
• Morita-Baylis-Hillman adduct
• aryl methyl oxidation
• isatin
• aromatic aldehydes

A simple, mild and efficient CAN mediated oxidation of Morita-Baylis-Hillman adducts of 5-methyl-N-alkylisatins 1a-13a to 5-formyl-N-alkylisatins lb-13b under ambient reaction conditions is reported. Simple and isomerized 5-methyl-N-alkylisatin derivatives 1-4 have also been tested and failed to provide the corresponding formylated products. A plausible reaction mechanism has been proposed.

• 出版日期2008-3-24