Antimicrobial activity against Gram-positive and Gram-negative bacteria during gatifloxacin degradation by hydroxyl radicals

作者：Caianelo Marlon; Rodrigues Silva Caio^*; Maniero Milena Guedes; Guimaraes Jose Roberto^*

来源：Environmental Science and Pollution Research, 2017, 24(7): 6288-6298.

DOI：10.1007/s11356-016-6972-y

• Acute toxicity
• Advanced oxidation process
• Antimicrobial activity
• Drinking water
• Fluoroquinolone degradation products
• UV/H2O2

Gatifloxacin, an antimicrobial drug belonging to the fluoroquinolone family, is active against Gram-positive and Gram-negative bacteria and is extensively used for the control of infections in humans. The presence of the drug in environmental matrices has already been reported. This study investigated the degradation of gatifloxacin in water by hydroxyl radicals generated by the UV254 nm/H2O2 process (CH2O2initial = 0.4-2.4 mmol L-1) and evaluated the capacity of the radicals to reduce the antimicrobial activity against Gram-positive and Gram-negative bacteria. Acute toxicity assays were performed with Vibrio fischeri, and the degradation products were proposed. The hydroxyl radicals formed in the processes were able to degrade the fluoroquinolone and remove the antimicrobial activity from the aqueous solution. Approximately 97 % gatifloxacin degradation was observed after applying 2.4 mmol L-1 of initial H2O2 concentration and 20 min of UVC254nm irradiation (130 J s(-1)). The acute toxicity assays showed that the toxicity of the treated solution for V. fischeri increased as the gatifloxacin concentration in the solution decreased.

• 出版日期2017-3