Acanthamoeba polyphaga Mimivirus Prevents Amoebal Encystment-Mediating Serine Proteinase Expression and Circumvents Cell Encystment

作者：Boratto Paulo; Albarnaz Jonas Dutra; de Freitas Almeida Gabriel Magno; Botelho Lucas; Lima Fontes Alide Caroline; Costa Adriana Oliveira; Santos Daniel de Assis; Bonjardim Claudio Antonio; La Scola Bernard; Kroon Erna Geessien; Abrahao Jonatas Santos^*

来源：Journal of Virology, 2015, 89(5): 2962-2965.

DOI：10.1128/JVI.03177-14

Acanthamoeba is a genus of free-living amoebas distributed worldwide. Few studies have explored the interactions between these protozoa and their infecting giant virus, Acanthamoeba polyphaga mimivirus (APMV). Here we show that, once the amoebal encystment is triggered, trophozoites become significantly resistant to APMV. Otherwise, upon infection, APMV is able to interfere with the expression of a serine proteinase related to amoebal encystment and the encystment can no longer be triggered.

• 出版日期2015-3