Low Birth Weight is Associated with Lower Respiratory Tract Infections in Children with Hand, Foot, and Mouth Disease

作者：Lu, Yong-Ping; Zeng, De-Ying; Chen, You-Peng^*; Liang, Xu-Jing; Xu, Jie-Ping; Huang, Si-Min; Lai, Zhi-Wei; Wen, Wang-Rong; von Websky, Karoline; Hocher, Berthold

来源：Clinical Laboratory, 2013, 59(9-10): 985-992.

DOI：10.7754/Clin.Lab.2012.120725

• hand
• foot and mouth disease (HFMD)
• low birth weight (LBW)
• lower respiratory tract infections (LRTIs)
• pneumonia
• children

Background: Low birth weight (LBW) might be a risk factor for acquiring lower respiratory tract infections (LRTIs) associated with disease related complications in early childhood. HFMD, a frequent viral infection in southern China, is a leading cause of lower respiratory tract infections in children. We analyzed whether LBW is a risk factor for children with HFMD to develop lower respiratory tract infections.
Methods: A total of 298 children with HFMD, admitted to a hospital in Qingyuan city, Guangdong province, were recruited. Demographic data and clinical parameters such as serum glucose level and inflammatory markers including peripheral white blood cell count, serum C-reactive protein, and erythrocyte sedimentation rate were routinely collected on admission. Birth weight data were derived from birth records.
Results: Mean birth weight (BW) was 167 g lower in patients with HFMD and LRTIs as compared to patients with solely HFMD (p = 0.022) and the frequency of birth weight below the tenth percentile was significantly higher in patients with HFMD and LRTIs (p = 0.002).
Conclusions: The results of the study show that low birth weight is associated with a higher incidence of lower respiratory tract infections in young children with HFMD.

• 出版日期2013
• 单位南方医科大学; 暨南大学