Anemia in patients with Wegener's granulomatosis

作者：Riegersperger M^*; Sengoelge G; Koeller M; Grossmann N; Benesch T; Sunder Plassmann G

来源：Clinical Nephrology, 2007, 67(3): 149-156.

• anemia
• vasculitis
• Wegener's granulomatosis
• rheumatology

Aims: Anemia is commonly observed among patients with chronic kidney disease (CKD). No such information is available for patients with a history of systemic vasculitis. Methods: We examined the prevalence of anemia, the response to therapy with erythropoicsis-stimulating agents (ESA), and the association of anemia with the kidney function in clinically stable patients with Wegener's granulomatosis in a retrospective, single-center study. Results: The mean hemoglobin concentration of 36 patients (mean age: 58 years; 15 female, 21 male; mean duration of disease: 4.6 years) was 13.0 +/- 2.1 g/dl, and the mean estimated glomerular filtration rate (eGFR) was 41 +/- 21 ml/min/1.73 m(2). 14 of 36 patients (38.8%) presented with anemia (hemoglobin concentration < 12 g/dl in women, < 13 g/dl in men, or ESA therapy). In patients with a CKD Stage 3 or 4, anemia was present about twice as much as compared to the Third National Health and Nutrition Examination Survey (NHANES III) population. The hemoglobin concentration, however, was not associated with a change of kidney p = 0.1578). Conclusions: We found a higher prevalence of anemia in patients with Wegener's granulomatosis, as compared to the NHANES III population. The hemoglobin concentrations showed no association with changes of kidney function.

• 出版日期2007-3
• 单位河北医科大学