Diterpenes inhibiting NO production from Euphorbia helioscopia

作者：Chen Hongqiang; Wang Hao; Yang Bo; Jin Da Qing; Yang Shuliang; Wang Meicheng; Xu Jing^*; Ohizumi Yasushi; Guo Yuanqiang

来源：Fitoterapia, 2014, 95: 133-138.

DOI：10.1016/j.fitote.2014.03.010

• Euphorbia helioscopia
• Jatrophane diterpene
• Inhibitory effects on NO production
• Diterpene

Three new jatrophane diterpenes (1-3), an unreported spectroscopic data jatrophane diterpenene (4), and nine known analogues (5-13) have been isolated from the whole plants of Euphorbia helioscopia. Their structures were established by detailed spectroscopic data analyses (IR, ESIMS, HR-ESIMS, and 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed inhibitory activities on LPS-induced NO production in murine microglial BV-2 cells.

• 出版日期2014-6
• 单位哈尔滨商业大学; 南开大学