Dragmacidol A and dragmacidolide A from the Australian marine sponge Dragmacidon australe

作者：Khokhar Shahan; Feng Yunjiang; Carroll Anthony R; Campitelli Marc R; Quinn Ronald J; Hooper John N A; Ekins Merrick G; Davis Rohan A^*

来源：Tetrahedron, 2015, 71(36): 6204-6209.

DOI：10.1016/j.tet.2015.06.087

• Dragmacidon australe
• Natural products
• Dragmacidol A
• Dragmacidolide A
• DFT-NMR

Two new secondary metabolites, the xylerythrin derivative dragmacidol A (1) and the steroid dragmacidolide A (2), were isolated from a specimen of the marine sponge Dragmacidon australe, collected off the coast of the Whitsunday Islands in Queensland, Australia. Their structures were fully characterized via analysis of 1D/2D NMR and MS data. The proton-poor structure of 1 was also supported through successful C-13 DFT-NMR calculations. The isolation of these two metabolites from this sponge genus is quite unusual, given that previous reports of Dragmacidon secondary metabolites have been dominated by indole and beta-carboline alkaloids.

• 出版日期2015-9-9