Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males

作者：Lund Michael Taulo^*; Taudorf Lrke; Hartmann Bolette; Helge Jorn Wulff; Holst Jens Juel; Dela Flemming

来源：European Journal of Applied Physiology, 2013, 113(11): 2737-2747.

DOI：10.1007/s00421-013-2711-y

• Insulin
• Incretin
• GLP-1
• GIP
• Exercise

Postprandial insulin release is lower in healthy aerobically trained (T) compared to untrained (UT) individuals. This may be mediated by a lower release of the two incretin hormones [glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] in T. The aim of this study was to assess and compare gut hormone response and satiety changes after a liquid meal intake in young, healthy T and UT males. Postprandial gut hormone release and subjective feelings of hunger, satiety, fullness and prospective food consumption were assessed before and frequently for the following 3 h after a 200 ml liquid meal (1,260 kJ and 27, 41 and 32 energy % as protein, carbohydrates and fat, respectively) in ten T and ten UT young, healthy male subjects. The insulin and GIP responses were markedly lower in T than UT and correlated during the first 30 min after the liquid meal. Baseline GLP-1 concentration was higher in T versus UT, but the response in the following 3 h after a liquid meal was similar in T and UT. Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.

• 出版日期2013-11