A secoiridoid with quinone reductase inducing activity from Cortex fraxini

作者:Wang Lijun; Sun Fang; Zhang Xiaoyu; Ma Zhongjun*; Cheng Lin
来源:Fitoterapia, 2010, 81(7): 834-837.
DOI:10.1016/j.fitote.2010.05.003

摘要

A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1,9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 +/- 7.7, 34.3 +/- 3.3 and 42.0 +/- 0.4 mu M respectively.

  • 出版日期2010-10
  • 单位浙江大学; 浙江省中医药研究院