Antifungal activity of some diaryl ethers

作者:Xu Hui*; Jian Kun Zhong; Guan Qiu; Ye Fei; Lv Min
来源:Chemical & Pharmaceutical Bulletin, 2007, 55(12): 1755-1757.
DOI:10.1248/cpb.55.1755

摘要

Several diaryl ethers were synthesized and tested in vitro against seven phytopathogenic fungi, namely Fusarium graminearum, Alternaria alternate, Helminthosporium sorokinianum, Pyricularia oryzae, Fusarium oxysporum f. sp. vasinfectum, Fusarium oxysporum f. sp. cucumarinum and Alternaria brassicae. Compared to a commercial agricultural fungicide, hymexazol, especially compounds a, b, e, g and k were found to be more effective at 50 mu g/ml against F. graminearum, F. oxysporum f. sp. vasinfectum and F. oxysporum f. sp. cucumarinum. Meantime, some structure-activity relationships were also observed.