Simulation of short-term pressure regulation during the tilt test in a coupled 3D-0D closed-loop model of the circulation

作者：Lau Kevin D; Figueroa C Alberto^*

来源：Biomechanics and Modeling in Mechanobiology, 2015, 14(4): 915-929.

DOI：10.1007/s10237-014-0645-x

• Baroreflex
• Blood flow
• Transitional
• Multi-scale
• Predictive

Short-term fluctuations in arterial pressures arising from normal physiological function are buffered by a negative feedback system known as the arterial baroreflex. Initiated by altered biomechanical stretch in the vessel wall, the baroreflex coordinates a systemic response that alters heart rate, cardiac contractility and peripheral vessel vasoconstriction. In this work, a coupled 3D-0D formulation for the short-term pressure regulation of the systemic circulation is presented. Including the baroreflex feedback mechanisms, a patient-specific model of the large arteries is subjected to a simulated head up tilt test. Comparative simulations with and without baroreflex control highlight the critical role that the baroreflex has in regulating variations in pressures within the systemic circulation.

• 出版日期2015-8