Association of interleukin-18 gene polymorphism with body mass index in women

作者：Kim Hye Lin; Cho Sung One; Kim Seon Young; Kim Sung Hoon; Chung Won Seok; Chung Seok Hee; Kim Sung Soo; Ko Seong Gyu; Jeong Chang Hyun; Kim Su Jin; Hong Seung Heon; Um Jae Young^*

来源：Reproductive Biology and Endocrinology, 2012, 10: 31.

DOI：10.1186/1477-7827-10-31

• Obesity
• Interleukin-18
• Polymorphism
• Korean

Background: Interleukin (IL)-18 is an important regulator of innate and acquired immune responses and has multiple roles in chronic inflammation and autoimmune disorders. Obesity is characterized by low- grade chronic inflammation. IL-18 has been suggested as an adipogenic cytokine that is associated with excess adiposity. The purpose of this study is to evaluate the relationship between IL-18 gene polymorphisms (-137 G/C and -607 C/A) and obesity. %26lt;br%26gt;Methods: All 680 subjects were genotyped for the polymorphisms of IL-18 gene promoters (at positions -137 G/C and -607 C/A) using a polymerase chain reaction (271 cases with BMI %26gt;= 25 kg/m(2) and 409 controls with BMI %26lt; 25 kg/m(2)). A chi-square test was used to compare the genotype and allele frequencies between the cases and control populations. %26lt;br%26gt;Results: Analyses of the genotype distributions revealed that IL-18 -607 C/A polymorphism was associated with an increase in body mass index in obese women in the Korean population (chi(2) = 12.301, df = 2, p = 0.015). %26lt;br%26gt;Conclusion: Carriage of the A allele at position -607 in the promoter of the IL-18 gene may have a role in the development of obesity.

• 出版日期2012-4-24