Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients

作者：Filho C B; Rodrigues F F; Segat L; Fonseca A M; Araujo J; Arahata C; Pontes L; Vilar L; de Lima Filho J L; Crovella S^*

来源：International Journal of Immunogenetics, 2012, 39(4): 357-361.

DOI：10.1111/j.1744-313X.2012.01102.x

We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95% CI: 1.112.26; P-value = 0.009) and HT (OR = 1.67, 95% CI: 1.092.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.

• 出版日期2012-8