Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

作者：Mylne Joshua S^*; Colgrave Michelle L; Daly Norelle L; Chanson Aurelie H; Elliott Alysha G; McCallum Emily J; Jones Alun; Craik David J

来源：Nature Chemical Biology, 2011, 7(5): 257-259.

DOI：10.1038/nchembio.542

The cyclic peptide sunflower trypsin inhibitor 1 (SFTI-1) blocks trypsin and is a promising drug lead and protein engineering scaffold. We show that SFTI-1 and the newfound SFT-L1 are buried within PawS1 and PawS2, precursors for seed storage protein albumins. Proalbumins are matured by asparaginyl endopeptidase, which we show is required to liberate both ends of SFTI-1 as well as to mature PawS1 albumin. Thus, these peptides emerge from within an albumin precursor by the action of albumin's own processing enzyme.

• 出版日期2011-5