Analysis of a Genome-Wide Association Study-Linked Locus (CCR6) in Asian Rheumatoid Arthritis

作者：Teng Esther; Leong Khai Pang; Li Hui Hua; Thong Bernard; Koh Ee Tzun^*; Loi Pooi Ling; Zhao Yi; Tan Eng King

来源：DNA and Cell Biology, 2012, 31(4): 607-610.

DOI：10.1089/dna.2011.1350

A genome-wide association study in Japan identified the C-C chemokine receptor type 6 gene (CCR6) as associated with rheumatoid arthritis (RA). This finding has not been validated in other Asian populations. A case-control study involving 996 subjects, comprising 440 controls and 556 RA patients, was done to determine their anticyclic citrullinated peptide (anti-CCP) antibody status and CCR6 polymorphism (rs3093024) genotype. Three hundred eighty-seven patients were anti-CCP positive and 153 anti-CCP negative. Logistic regression showed that allele A was likely to increase the risk of developing RA among females via a recessive model (odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.01, 2.39), whereas the risk effect appeared to be reduced among males via an additive model (OR = 0.60, 95% CI = 0.42, 0.85). Considering only subjects who are anti-CCP positive, allele A increased RA risk among females via a recessive model (OR = 1.68, 95% CI = 1.07, 2.64) but decreased the risk among males via an additive model (OR = 0.59, 95% CI = 0.39, 0.89). We showed that CCR6 polymorphism was a risk factor among females but a protective factor among males. Functional studies are warranted to unravel the pathophysiological relevance of the gene variant and other linked variants with RA.

• 出版日期2012-4