Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

作者：Takatoh Jun; Wang Fan^*

来源：Neuron, 2012, 74(1): 3-5.

DOI：10.1016/j.neuron.2012.03.012

Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of Neuron, Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.

• 出版日期2012-4-12