Xeroderma Pigmentosum Complementation Group F Polymorphisms Influence Risk of Glioma

作者：Cheng Hong Bin; Xie Chen; Zhang Ru You; Hu Shao Shan; Wang Zhi; Yue Wu^*

来源：Asian Pacific Journal of Cancer Prevention, 2013, 14(7): 4083-4087.

DOI：10.7314/APJCP.2013.14.7.4083

• Xeroderma pigmentosum complementation group F
• single nucleotide polymorphisms
• glioma

We conducted an exploratory investigation of whether variation in six common SNPs of xeroderma pigmentosum complementation group F (XPF) is associated with risk of glioma in a Chinese population. Six single nucleotide polymorphisms (SNPs) were genotyped in 207 glioma cases and 236 cancer-free controls by a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). The rs1800067 G and rs2276466 G allele frequencies were significantly higher in the glioma group than controls. Individuals with the rs1800067 GG genotype were at greater risk of glioma when compared with the A/A genotype in the codominant model, with an OR (95% CI) of 2.63 (1.04-7.25). The rs2276466 polymorphism was significantly associated with moderate increased risk of glioma in codominant and dominant models, with ORs (95% CI) of 1.90 (1.05-3.44) and 1.55 (1.07-2.47), respectively. The combination genotype of rs1800067 G and rs2276466 G alleles was associated with a reduced risk of glioma (OR=0.44, 95% CI=0.19-0.98). These findings indicate that genetic variants of the XPF gene have critical functions in the development of glioma.

• 出版日期2013
• 单位哈尔滨医科大学