Alkali Salt of L-Proline as an Efficient and Practical Catalyst for the Cyanosilylation of a Wide Variety of Carbonyl Compounds Under Solvent-Free Conditions

作者：Shen Zhi Liang; Ji Shun Jun^*

来源：Synthetic Communications, 2009, 39(5): 775-791.

DOI：10.1080/00397910802431149

• Cyanohydrin
• cyanosilylation
• L-proline salt
• solvent-free condition
• TMSCN

The alkali salt of L-proline was demonstrated to be an efficient and practical catalyst for the cyanosilylation of a wide variety of simple and functionalized carbonyl compounds under solvent-free conditions. The reactions proceeded smoothly at room temperature to afford the corresponding cyanohydrins in good to excellent yields.

• 出版日期2009
• 单位苏州大学