Association Between Inflammatory Biomarkers and Bone Mineral Density in a Community-Based Cohort of Men and Women

作者：Sponholtz Todd R; Zhang Xiaochun; Fontes Joao D T; Meigs James B; Cupples L Adrienne; Kiel Douglas P; Hannan Marian T; McLean Robert R^*

来源：Arthritis Care & Research, 2014, 66(8): 1233-1240.

DOI：10.1002/acr.22270

Objective. Based upon evidence in animal and in vitro studies, we tested the hypothesis that higher serum concentrations of the cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha) and the inflammatory marker C-reactive protein (CRP) would be inversely associated with bone mineral density (BMD) in a community-based cohort of men and women, with the strongest associations among postmenopausal women not receiving menopause hormonal therapy (MHT).
Methods. We ascertained fasting serum concentrations of IL-6, TNF alpha, and CRP and measured BMD at the femoral neck, trochanter, total femur, and spine (L2-L4) using dual x-ray absorptiometry in 2,915 members of the Framingham Offspring Study (1996-2001). We used multivariable linear regression to estimate the difference (beta) in BMD at each bone site associated with a 1-unit increase in log-transformed serum concentrations of IL-6, TNF alpha, and CRP separately for men (n = 1,293), premenopausal women (n = 231), postmenopausal women receiving MHT (n = 498), and postmenopausal women not receiving MHT (n = 893).
Results. Inflammatory biomarkers were not associated with BMD in men. Among premenopausal women, there were statistically significant, modest inverse associations between IL-6 and trochanter BMD (beta = 0.030, P < 0.01) and between CRP and femoral neck (beta = 0.015, P = 0.05) and trochanter BMD (beta = -0.014, P = 0.04). TNF alpha was positively associated with spine BMD (beta = 0.043, P = 0.01). In postmenopausal women receiving MHT, CRP was positively associated with femoral neck BMD (beta = 0.011, P = 0.04). There were no associations among postmenopausal women not receiving MHT.
Conclusion. The lack of consistency in our results suggests that elevated circulating concentrations of inflammatory biomarkers may not be a risk factor for low BMD.

• 出版日期2014-8