An Efficient Three-Component Synthesis of 3-(5-Alkyl/aryl-1,3,4-oxadiazol-2-yl)-3-hydroxy-1,3-dihydro-2H-indol-2-o nes

作者：Adib Mehdi^*; Sheikhi Ehsan; Kavoosi Azadeh; Bijanzadeh Hamid Reza

来源：Synthesis (Germany), 2010, 2010(23): 4082-4086.

DOI：10.1055/s-0030-1258300

• N-isocyaniminotriphenylphosphorane
• isatins
• carboxylic acids
• 1,3,4-oxadiazoles
• multi-component reactions
• heterocycles
• cyclizations

An efficient three-component synthesis of 3-(1,3,4-oxadiazol-2-yl)-3-hydroxy-1,3-dihydro-2H-indol-2-ones is described. A mixture of N-isocyaniminotriphenylphosphorane, an isatin, and a carboxylic acid undergoes a 1:1:1 addition reaction under mild conditions to afford the title compounds in excellent yields.

• 出版日期2010-12