Assessment of Key Amino-Acid Residues of CD36 in Specific Binding Interaction with an Oxidized Low-Density Lipoprotein

作者：Takai Marie; Tsuzuki Satoshi^*; Matsuno Yukari; Kozai Yuki; Eguchi Ai; Matsumura Shigenobu; Inoue Kazuo; Fushiki Tohru

来源：Bioscience Biotechnology and Biochemistry, 2013, 77(5): 1134-1137.

DOI：10.1271/bbb.130072

• CD36
• hydrophobic residues
• oxidized low-density lipoprotein/oxidized glycerophospholipids
• specific binding
• synthetic peptides

CD36 binds oxidized low-density lipoprotein (oxLDL). A synthetic peptide comprising amino-acid residues 149-168 of mouse CD36 was recently found to bind fluorescence-labeled oxLDL particles. Based on our oxLDL-binding analysis of various synthetic CD36 peptides, we suggest that not only hydrophilic residues (e.g., Lys164 and Lys166) but also hydrophobic ones (e.g., Phe153, Leu158, and Leu161) are critical to binding.

• 出版日期2013-5