N,N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents

作者：Olar Rodica^*; Badea Mihaela; Marinescu Dana; Chifiriuc Mariana Carmen; Bleotu Coralia; Grecu Maria Nicoleta; Iorgulescu Emilia Elena; Lazar Veronica

来源：European Journal of Medicinal Chemistry, 2010, 45(7): 3027-3034.

DOI：10.1016/j.ejmech.2010.03.033

• Antimicrobial activity
• Bacterial biofilm
• Cytotoxicity
• Complex
• N,N-dimethylbiguanide

The new complexes M(DMBG)(2)(ClO(4))(2) (M:Mn, Ni, Cu and Zn; DMBG: N,N-dimethylbiguanide) have been synthesized and characterized by IR, EPR, (1)H NMR, (13)C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)(2)](ClO(4))(2)center dot 2DMF (DMF: N,N-dimethylformamide) crystallizes in the monoclinic P2 (1)/c space group while [Cu(DMBG)(2)](ClO(4))(2) adopt monoclinic P21/c space group as X-ray single crystal data indicate. The redox behavior of complexes was investigated by cyclic voltammetry. The metal-free N, N-dimethylbiguanide and complexes exhibit specific anti-infective properties as demonstrated the low MIC values, a large antimicrobial spectrum and also inhibit the ability of Pseudomonas aeniginosa and Staphylococcus aureus strains to colonize the inert surfaces. The complexes exhibit also a low cytotoxicity levels on HeLa cells.

• 出版日期2010-7