Directed evolution of a synthetic RNA-protein module to create a new translational switch

作者：Hara Tomoaki; Saito Hirohide^*; Inoue Tan

来源：Chemical communications, 2013, 49(37): 3833-3835.

DOI：10.1039/c3cc38688k

A synthetic RNP-binding module was developed to produce an alternative translational switch: an in vitro selection experiment targeting a derivative of L7Ae protein (L7KK) identified a new H23 RNA aptamer that binds tightly to both L7KK and L7Ae. The switch serves as a translational OFF switch for constructing a NOR gate.

• 出版日期2013