Anticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp

作者：Czaikoski Paula G; Menaldo Danilo L; Marcussi Silvana; Baseggio Anne L C; Fuly Andre L; Paula Rafael C; Quadros Andreza U; Romao Pedro R T; Buschini Maria L T; Cunha Fernando Q; Soares Andreimar M; Monteiro Marta C^*

来源：Blood Coagulation & Fibrinolysis, 2010, 21(7): 653-659.

DOI：10.1097/MBC.0b013e32833cea7a

• anticoagulant activity
• fibrinogenolytic activity
• Polybia occidentalis
• social wasp
• venom

Previous studies have shown that venoms of social wasps and bees exhibit strong anticoagulant activity. The present study describes the anticoagulant and fibrinogen-degrading pharmacological properties of the venom of Polybia occidentalis social wasp. The results demonstrated that this venom presented anticoagulant effect, inhibiting the coagulation at different steps of the clotting pathway (intrinsic, extrinsic and common pathway). The venom inhibited platelet aggregation and degraded plasma fibrinogen, possibly containing metal-dependent metalloproteases that specifically cleave the B beta-chain of fibrinogen. In conclusion, fibrinogenolytic and anticoagulant properties of this wasp venom find a potential application in drug development for the treatment of thrombotic disorders. For that, further studies should be carried out in order to identify and isolate the active compounds responsible for these effects.

• 出版日期2010-10