Melonoside A: An omega-Glycosylated Fatty Acid Amide from the Far Eastern Marine Sponge Melonanchora kobjakovae

作者：Guzii Alla G; Makarieva Tatyana N^*; Denisenko Vladimir A; Dmitrenok Pavel S; Kuzmich Aleksandra S; Dyshlovoy Sergey A; von Am**erg Gunhild; Krasokhin Vladimir B; Stonik Valentin A

来源：Organic Letters, 2016, 18(14): 3478-3481.

DOI：10.1021/acs.orglett.6b01678

Melonoside A (1), the first representative of a new class of omega-glycosylated fatty acid amides, was isolated from the Far Eastern marine sponge Melonanchora kobjakovae. The structure of 1, including absolute configuration, was established using detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound 1 induces autophagy of human cisplatin-resistant germinal tumor cells NCCIT-R.

• 出版日期2016-7-15