Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes

作者：Taslimi Parham^*; Gulcin Ilhami

来源：Journal of Biochemical and Molecular Toxicology, 2017, 31(10): e21956.

DOI：10.1002/jbt.21956

• -amylase
• -glycosidase
• enzyme inhibition
• phenolic compounds

-Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into simple absorbable sugar units. The natural phenolic compounds were tested for their antidiabetic properties as -glycosidase and -amylase inhibitors. The phenolic compounds investigated in this study have been used as antidiabetic common medicines. This paper aimed to consider their capability to inhibit -amylase and -glycosidase, two significant enzymes defined in serum glucose adjustment. These examination recorded impressive inhibition profiles with IC50 values in the range of 137.36-737.23nM against -amylase and 29.01-157.96nM against -glycosidase.

• 出版日期2017-10