Genetic encoding of the post-translational modification 2-hydroxyisobutyryl-lysine

作者:Knight William A; Cropp T Ashton*
来源:Organic and Biomolecular Chemistry, 2015, 13(23): 6479-6481.
DOI:10.1039/c5ob00283d

摘要

We report the synthesis and genetic encoding of a recently discovered post-translational modification, 2-hydroxyisobutyryl-lysine, to the genetic code of E. coli. The production of homogeneous proteins containing this amino acid will facilitate the study of modification in full-length proteins.

  • 出版日期2015