科研之友
微信
新浪微博
Facebook
分享链接
摘要
Telomerase activity is the key modulator of most of the cancer cells. Telomerase, a reverse transcriptase, has been found to be activated in more than 80% of human cancers and, therefore, can be considered as a potential marker for tumorigenesis. The ability of curcumin indicates the possibility of developing as a potential universal cancer chemoprevention and chemotherapeutic agent. Curcumin may regulate multi-targeted human therapy. The present investigation is made to review the nanoparticle-curcumin complex in the detection and regulation of telomerase activity. Nanoparticles encapsulated curcumin like nanocurcumin are one of the major means that could be used to improve bioavailability of curcumin. Nanoparticle mediated delivery of curcumin like nanoparticle encapsulated curcumin, barbicode assay, curcumin embedding phospholipids vesicles or lipid-nanospheres, liposome mediated curcumin drug delivery system and curcumin analogues are extensively reviewed. Therefore, nanoparticle curcumin complex could be clinically acceptable carrier for the regulation of telomerase activity of most of the cancer cells as well as development of novel therapeutic agents. Thus potentials of curcumin could be multifold enhanced and clinically significant.
- 出版日期2008-12
