Alkaloids from Hippeastrum morelianum Lem. (Amaryllidaceae)

作者：Giordani Raquel B; de Andrade Jean P; Verli Hugo; Dutilh Julie H; Henriques Amelia T; Berkov Strahil; Bastida Jaume; Zuanazzi Jose Angelo S^*

来源：Magnetic Resonance in Chemistry, 2011, 49(10): 668-672.

DOI：10.1002/mrc.2794

• NMR
• H-1 NMR
• C-13 NMR
• 2 alpha,7-dimethoxyhomolycorine
• candimine
• homolycorine-type alkaloids
• Hippeastrum morelianum
• Amaryllidaceae

The Amaryllidaceae family has proven to be a rich source of active molecules. As part of an ongoing project, we report a phytochemical study of Hippeastrum morelianum (Amaryllidaceae), from which we have isolated two homolycorine-type alkaloids, the new 2 alpha,7-dimethoxyhomolycorine (1) and the poorly described candimine (2), as well as six known alkaloids: tazettine, pretazettine, 3-epimacronine, haemanthamine, hamayne and trisphaeridine. For reference purposes, the NMR of the isolated compounds was unequivocally described, based on 2D NMR measurements including H-1-H-1 COSY, H-1-H-1 NOESY, HSQC and HMBC.

• 出版日期2011-10