A polymorphism in the angiotensin II type 1 receptor gene has different effects on the risk of diabetic nephropathy in men and women

作者：Mollsten Anna^*; Vionnet Nathalie; For**lom Carol; Parkkonen Maija; Tarnow Lise; Hadjadj Samy; Marre Michel; Parving Hans Henrik; Groop Per Henrik

来源：Molecular Genetics and Metabolism, 2011, 103(1): 66-70.

DOI：10.1016/j.ymgme.2011.01.004

• A1166C
• Angiotensin II type 1 receptor
• Diabetic nephropathy
• Renin-angiotensin system
• rs5186
• Type 1 diabetes

Background: The etiology of diabetic nephropathy depends partly on genetic factors. Elevated systemic and intraglomerular blood pressure and glomerular filtration rate, partly regulated by the renin-angiotensin system, increase the risk of diabetic nephropathy.
Methods: The present case-control study investigated the association of the rs5186 polymorphism, in the angiotensin II type 1 receptor gene (AGTR1), with diabetic nephropathy. The study included 3561 patients with type 1 diabetes from Denmark, Finland, France and Sweden. Microalbuminuria was defined as albumin excretion rate (AER) >= 20 to < 200 mu g/min or albumin concentration >= 30 to < 300 mg/l (n = 707), macroalbuminuria was defined as AER >= 200 mu g/min or 300 mg/l (n = 1546), and patients with renal replacement therapy were also included in this group. The controls had > 15 years diabetes duration, AER < 20 mu g/min or < 30 mg/l, and no antihypertensive treatment (n=1308).
Results: AA genotype of the rs5186 polymorphism significantly increased the risk of diabetic nephropathy in male patients, OR=1.27 (95% CI = 1.02-1.58), P=0.03, adjusted for age at diabetes onset. HbA1c, diabetes duration, smoking and country of origin. Among the women, there were no significant associations between rs5186 and diabetic nephropathy, OR=0.89 (0.71-1.11), P=0.30.
Conclusion: We conclude that the AGTR1 gene may be associated with increased risk of diabetic nephropathy in men with type 1 diabetes.

• 出版日期2011-5