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摘要
A novel enzymeless glucose sensor based on overoxidized polypyrrole (oPPy) modified on a selfmade nickel microelectrode has been fabricated. The electrocatalytic oxidation of glucose in alkaline medium directly at the modified microelectrode has been investigated and which shows excellent electrocatalytic activity towards glucose oxidation at low positive potential of 0.47 V (vs. Ag/AgCl, saturated with KCl) and relative alkalescence solution of pH 12. Glucose was determined chronoamperometrically at the surface of the modified disk-microelectrode in 0.01 mol/L NaOH solution. Under the optimized condition, the calibration curve is linear in the concentration range of 5.0 x 10-(6) - 1.1 x 10(-3) mol/L with a detection limit of (SIN = 3) 2.4 x 10(-6) mol/L and sensitivity of 30.4 nA (mu mol/L)(-1), respectively. The glucose sensor has short response time (within 3 s) and can be renewed easily in a reproducible manner by a simple polishing step. In addition, the capabilities of anti-interference and application for direct glucose quantitative analysis by means of FIA in human blood serum are also discussed.
- 出版日期2008-9
- 单位桂林理工大学
