Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer

作者：Tolaney Sara M^*; Tan Sally; Guo Hao; Barry William; Van Allen Eliezer; Wagle Nikhil; Brock Jane; Larrabee Katherine; Paweletz Cloud; Ivanova Elena; Janne Pasi; Overmoyer Beth; Wright John J; Shapiro Geoffrey I; Winer Eric P; Krop Ian E

来源：Investigational New Drugs, 2015, 33(5): 1108-1114.

DOI：10.1007/s10637-015-0269-8

• Triple-negative breast cancer
• Tivantinib
• MET
• ARQ 197

Background MET expression and activation appear to be important for initiation and progression of triple-negative breast cancer. Tivantinib (ARQ 197) is an orally administered agent that targets MET, although recent preclinical data suggests the agent may have mechanisms of action that are independent of MET signaling. We conducted a phase 2 study of tivantinib monotherapy in patients with metastatic triple-negative breast cancer. Methods Patients with metastatic triple-negative breast cancer who had received 1 to 3 prior lines of chemotherapy in the metastatic setting were enrolled into this two-stage, single arm phase 2 study. Treatment consisted of twice daily oral dosing of tivantinib (360 mg po bid) during a 21-day cycle. Patients underwent restaging scans at 6 weeks, and then every 9 weeks. Tumor biomarkers that might predict response to tivantinib were explored. Results 22 patients were enrolled. The overall response rate was 5 % (95 % CI 0-25 %) and the 6-month progression-free survival (PFS) was 5 % (95 % CI 0-25 %), with one patient achieving a partial response (PR). Toxicity was minimal with only 5 grade >= 3 adverse events (one grade 3 anemia, one grade 3 fatigue, and 3 patients with grade 3/4 neutropenia). Conclusion This study represents the first evaluation of tivantinib for the treatment of metastatic triple-negative breast cancer. These results suggest that single agent tivantinib is well tolerated, but did not meet prespecified statistical targets for efficacy.

• 出版日期2015-10