A New Electrochemical HbA1c Biosensor Based on Flow Injection and Screen-Printed Electrode

作者:Liu, Ang; Xu, Shaorui; Deng, Hongyu; Wang, Xiaochun*
来源:International Journal of Electrochemical Science, 2016, 11(4): 3086-3094.
DOI:10.20964/110403086

摘要

In this paper a novel elctrochemical HbA(1c) biosensor based on flow injection and screen-printed electrode was developed. The reticulated vitreous carbon (RVC) electrode was modified with 3aminophenylboronic acid, chitosan (CS), and tetraenthoxyl silica (TEOS), which entrapped carbon nanotubes to form a sol-gel film at the surface of the screen-printed electrode. The electrochemical behavior of the biosensor was investigated using cyclic voltammograms and amperometric method. Then the reusability of RVC electrode was investigated at various pH values. Furthermore, the selectivity and stability of the HbA1c biosensor was studied. The biosensor was also employed to detect the real samples, and the results were compared to automatic biochemical analysis.