A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits

作者：Gui Jiang; Moore Jason H^*; Williams Scott M; Andrews Peter; Hillege Hans L; van der Harst Pim; Navis Gerjan; Van Gilst Wiek H; Asselbergs Folkert W; Gilbert Diamond Diane

来源：PLos One, 2013, 8(6): e66545.

DOI：10.1371/journal.pone.0066545

We present an extension of the two-class multifactor dimensionality reduction (MDR) algorithm that enables detection and characterization of epistatic SNP-SNP interactions in the context of a quantitative trait. The proposed Quantitative MDR (QMDR) method handles continuous data by modifying MDR%26apos;s constructive induction algorithm to use a T-test. QMDR replaces the balanced accuracy metric with a T-test statistic as the score to determine the best interaction model. We used a simulation to identify the empirical distribution of QMDR%26apos;s testing score. We then applied QMDR to genetic data from the ongoing prospective Prevention of Renal and Vascular End-Stage Disease (PREVEND) study.

• 出版日期2013-6-21