Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression

作者：Isobe Tomoyasu; Song Soken Nakazawa J; Tiwari Prabha; Ito Hiroki; Yamaguchi Yuki; Yoshizaki Kazuyuki^*

来源：FEBS Letters, 2013, 587(16): 2487-2492.

DOI：10.1016/j.febslet.2013.06.028

• AID
• Demethylation
• Pax5

DNA methylation is a well-characterized epigenetic landmark involved in transcriptional regulation; however, mechanisms underlying its regulation remain poorly characterized. Recent studies demonstrate that activation-induced cytidine deaminase (AID) is involved in active DNA demethylation. AID is aberrantly expressed in inflammation-associated cancers and generates point mutations; however, cellular disorders attributed to its demethylation function are largely unexplored. Here we demonstrate that ectopic AID expression perturbs tumor-related gene expression. AID (with Gadd45) activated a methylated paired box gene 5 (Pax5) reporter construct, and induced expression and association of endogenous Pax5 with the AID promoter, suggesting that aberrant AID expression triggers an auto-activation circuit to consolidate self-expression.
Structured summary of protein interactions:
AID phy

• 出版日期2013-8-19