A facile one-pot synthesis of 2-(2-pyridyl)quinolines via Povarov reaction

作者：Borel Carmindo Ribeiro; Almeida Barbosa Luiz Claudio; Alvares Maltha Celia Regina; Fernandes Sergio Antonio

来源：Tetrahedron Letters, 2015, 56(5): 662-665.

DOI：10.1016/j.tetlet.2014.12.016

• Streptonigrin
• Pyridylquinoline
• Multicomponent reactions
• Quinoline synthesis
• Povarov reaction

An efficient synthesis of 2-(2-pyridyl)quinolines was achieved via a three-component Povarov reaction of aromatic aldehydes, anilines, and ethyl vinyl ether under boron trifluoride methyl etherate (BF3 center dot O(CH3)(2)) acid catalysis. The developed methodology for the preparation of 2-(2-pyridyl)quinolines offers several advantages over previous methods including mild reaction conditions, easy work-up, a wide range of substrate applicability, and products in good yields.

• 出版日期2015-1-28