A way to prepare core-shell biocompatible polymeric nano-particles from gelatin and acrylic acid

作者：Wang Zhouxi; Zhang Youwei^*; Wang Yansong; Zhao Jiongxin; Wu Chengxun

来源：Journal of Macromolecular Science Part A-Pure and Applied Chemistry, 2006, 43(11): 1779-1786.

DOI：10.1080/10601320600939635

• nano-particles
• interpolymer complex
• in situ polymerization
• pH-response
• biocompatible
• high-concentration

Narrowly distributed core-shell nano-particles at relatively high concentration ( 30 mg/mL) were prepared via in situ polymerization of acrylic acid in an aqueous solution of biocompatible gelatin. These polymeric nano-particles, in aqueous solution, had cores mainly comprised of an insoluble inter-polymer complex of poly ( acrylic acid, PAA) and gelatin and shells comprised of soluble gelatin ( denoted as gelatin/PAA nano-particles). Dynamic light scattering and electrophoretic light scattering techniques were used to trace the in situ polymerization process. The structure of the gelatin/ PAA nano-particle was further locked-in via shell crosslinking; i.e., the reaction between glutaraldehyde and gelatin. Scanning force microscopy (SFM) was used to observe the morphologies of the particles before and after cross-linking. Furthermore, the pH responsive behaviors of the gelatin/ PAA nano-particles before and after shell crosslinking were studied.

• 出版日期2006
• 单位东华大学