Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor-Positive and -Negative Breast Cancer: a Nested Case-Control Study

作者：James Rebecca E; Lukanova Annekatrin; Dossus Laure; Becker Susen; Rinaldi Sabina; Tjonneland Anne; Olsen Anja; Overvad Kim; Mesrine Sylvie; Engel Pierre; Clavel Chapelon Francoise; Chang Claude Jenny; Vrieling Alina; Boeing Heiner; Schuetze Madlen; Trichopoulou Antonia; Lagiou Pagona; Trichopoulos Dimitrios; Palli Domenico; Krogh Vittorio; Panico Salvatore; Tumino Rosario; Sacerdote Carlotta; Rodriguez Laudina; Buckland Genevieve; Sanchez Maria Jose; Amiano Pilar

来源：Cancer Prevention Research, 2011, 4(10): 1626-1635.

DOI：10.1158/1940-6207.CAPR-11-0090

Prediagnostic endogenous sex steroid hormone levels have well established associations with overall risk of breast cancer. While evidence toward the existence of distinct subtypes of breast cancer accumulates, few studies have investigated the associations of sex steroid hormone levels with risk of hormone receptor [estrogen receptor (ER) and/or progesterone receptor (PR)] defined breast cancer. In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. A total of 554 women who developed invasive breast cancer with information on receptor status were matched with 821 control subjects. Conditional logistic regression models estimated breast cancer risk with hormone concentrations according to hormone receptor status of the tumor. Sex steroid hormones were associated with risks of not only ER+PR+ breast cancer [estradiol OR for highest vs. lowest tertile = 2.91 (95% CI: 1.62-5.23), P-trend 0.002; testosterone OR = 2.27 (95% CI: 1.35-3.81), P-trend 0.002] but also of ER-PR- breast cancer [estradiol OR = 2.11 (95% CI: 1.00-4.46), P-trend = 0.05; testosterone OR = 2.06 (95% CI: 0.95-4.46), P-trend = 0.03], with associations appearing somewhat stronger in the receptor-positive disease. Serum androgens and estrogens are associated with risks of both hormone receptor-negative as well as receptor-positive breast tumors. Further research is needed to establish through which molecular pathways, and during which evolutionary stages of development, androgens and estrogens can promote the occurrence of both receptor-positive and -negative clinical breast tumors. Cancer Prev Res; 4(10); 1626-35.

• 出版日期2011-10