Complex karyotype predicts for inferior outcomes following reduced-intensity conditioning allogeneic transplant for chronic lymphocytic leukaemia

作者：Jaglowski Samantha M^*; Ruppert Amy S; Heerema Nyla A; Bingman Anissa; Flynn Joseph M; Grever Michael R; Jones Jeffrey A; Elder Patrick; Devine Steven M; Byrd John C; Andritsos Leslie A

来源：British Journal of Haematology, 2012, 159(1): 82-87.

DOI：10.1111/j.1365-2141.2012.09239.x

• chronic lymphocytic leukaemia
• transplant
• fluorescent insitu hybridization
• metaphase cytogenetics
• conditioning

Complex karyotype (CK) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (CLL) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. Fifty-one CLL patients were analysed following transplant; 18-month overall survival (OS), event-free survival (EFS) and cumulative incidence of progression estimates were 35%, 14% and 63%, respectively, in patients with CK (n=19) versus 83%, 68% and 29% in patients without (n=32) (P=0.0001, P=0.0001, and P=0.02). In patients with high-risk interphase cytogenetics, CK remained predictive of worse OS (P=0.02) and EFS (P=0.009). These findings support further evaluation of metaphase karyotype in transplant risk assessment.

• 出版日期2012-10