A method for the regioselective synthesis of 1-alkyl-1H-indazoles

作者：Liu Han Jun; Hung Shiang Fu; Chen Chuan Lin; Lin Mei Huey^*

来源：Tetrahedron, 2013, 69(19): 3907-3912.

DOI：10.1016/j.tet.2013.03.042

• Regioselective
• Indazoles
• 2-Halobenzonitriles
• N-Alkylhydrazines
• Deamination

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles followed by reductive deamination.

• 出版日期2013-5-13