Stability of Tilo (R) tablets formulation obtained from dry extract of Justice pectoralis Jacq.

作者：Rodriguez Chanfrau Jorge E^*; Nunez Figueredo Yanier; Fuste Moreno Viviana

来源：Brazilian Journal of Pharmaceutical Sciences, 2015, 51(1): 193-202.

DOI：10.1590/S1984-82502015000100019

• Justicia pectoralis/pharmacognosy
• Medicinal plants
• Phytomedicines
• Coumarins/determination
• High Performance Liquid Chromatography/phytomedicines analysis
• Phytomedicines/stability studies
• Tilo (R)/tablets/stability studies

Justicia pectoralis Jacq., Acanthaceae, is a herb known popularly in Cuba as Tilo and used traditionally as sedative. The development in a solid pharmaceutical (Tablets 100 mg) using dry extract of Justicia pectolaris aqueous extract is of interest for the development of phytomedicines, which uses this active raw material. The aim of the present study was to carry out chemical and biological stability studies to the formulation. A method of coumarin determination by High Performance Liquid Chromatography (HPLC) was used and validated. The stability studies during different periods of time (24 months) showed a stability of the product stored at 32 +/- 2 degrees C, and protected of the light.

• 出版日期2015-3