Analysis of the Enol-Keto Tautomers of Indole-3-pyruvic Acid

作者:Tivendale Nathan D; Davies Noel W; Horne James; Ross John J; Smith Jason A*
来源:Australian Journal of Chemistry, 2015, 68(2): 345-348.
DOI:10.1071/CH14343

摘要

Indole-3-pyruvic acid (IPyA) is an important naturally occurring biosynthetic intermediate whose quantitation by standard analytic techniques can be complicated as it can exist as either the keto or enol tautomer. Here, we present a detailed analysis of the tautomerism of IPyA and provide further evidence that the two tautomers of IPyA may be readily separated by ultra high-performance liquid chromatography and that the relative proportions of each form may be controlled using temperature and pH.

  • 出版日期2015