Neolignans from leaves of Miliusa mollis

作者：Sawasdee Kanok****; Chaowasku Tanawat; Lipipun Vimolmas; Thi Hanh Dufat; Michel Sylvie; Likhitwitayawuid Kittisak^*

来源：Fitoterapia, 2013, 85: 49-56.

DOI：10.1016/j.fitote.2012.12.028

• Neolignans
• Structure elucidation
• Cytotoxicity
• Anti-herpes simplex virus
• Miliusa mollis
• Annonaceae

From the leaves of Miliusa mollis Pierre (Annonaceae), five new dihydrobenzofuran neolignans, namely miliumollin, 7-methoxymiliumollin, 3%26apos;-methoxymiliumollin, 4%26apos;-O-methylmiliumollin and miliumollinone, and a new 8-O-4%26apos; neolignan named miliusamollin were isolated, and their structures were elucidated through analysis of spectroscopic data. Miliumollin, 3%26apos;-methoxymiliumollin, miliumollinone and decurrenal exhibited weak cytotoxicity against KB, MCF7 and NCI-H187 cells. Miliumollinone possessed weak inhibitory effects against herpes simplex virus types 1 and 2. None of the isolates displayed inhibitory activity against avian influenza H5N1 neuraminidase.

• 出版日期2013-3