Adherence therapy following an acute episode of schizophrenia: A multi-centre randomised controlled trial

作者：Schulz Michael; Gray Richard^*; Spiekermann Alexa; Abderhalden Christoph; Behrens Johann; Driessen Martin

来源：Schizophrenia Research, 2013, 146(1-3): 59-63.

DOI：10.1016/j.schres.2013.01.028

• Adherence
• Compliance
• Antipsychotic
• Schizophrenia

Background: Non-adherence with antipsychotic medication is common in patients with schizophrenia. %26lt;br%26gt;Aims: To establish the efficacy of adherence therapy (AT) compared to treatment as usual (TAU) in improving medication compliance in patients following an acute episode of schizophrenia. %26lt;br%26gt;Method: The study was designed as a parallel group, single blind, randomised controlled trial. Fieldwork was conducted in four centres (3 in Germany and 1 in Switzerland) and involved a total of 161 patients. Patients received 8 sessions of AT in addition to treatment as usual. The main outcomes of this study were adherence and psychopathology at 12 weeks post discharge follow up. %26lt;br%26gt;Results: In total 80 patients received AT and 57 TAU. Intention-to-treat analysis included all randomised patients. Psychopathology, as determined using the PANSS-total, improved in the AT compared to TAU group by a mean of -6.16 points 12 weeks after discharge from hospital (p%26lt;.05). AT had no significant effects on patients%26apos; adherence, treatment attitudes or functioning. No significant adverse events were reported. %26lt;br%26gt;Conclusion: AT improves psychopathology in patients recovering from an acute episode of schizophrenia.

• 出版日期2013-5