Associations Between Individual Lower Urinary Tract Symptoms and Bacteriuria in Random Urine Samples in Women

作者：Sorrentino Felice^*; Cartwright Rufus; Digesu G Alessandro; Tolton Louise; Franklin Larissa; Singh Anand; Greco Pantaleo; Khullar Vik

来源：Neurourology and Urodynamics, 2015, 34(5): 429-433.

DOI：10.1002/nau.22607

• bacteriuria
• incontinence
• LUTS
• OAB
• urinary tract infection

Aims: Previous studies have noted an association between a diagnosis of overactive bladder and bacteriuria, but little is understood about the relationship of bacteriuria to specific LUTS. We hypothesized that bacteriuria in women would be associated with increased self-reported symptom scores for a wide range of LUTS. Methods: Women were recruited from general gynecology and urogynecology outpatient clinics in a secondary care setting. Women completed the 12-item International Consultation on Incontinence Questionnaire for Female Lower Urinary Tract Symptoms and provided a clean-catch mid-stream specimen of urine for microscopy and culture. Women with acute urinary tract infection were excluded. Three statistical approaches (Mann-Whitney U-test, multivariable logistic regression, and receiver operating characteristic curves) were used to assess differences in symptom scores between women with and without bacteriuria. Results: Two hundred forty-seven women were recruited, aged 22-82. Sixteen of 247 urine samples (6.5%) demonstrated significant bacteriuria, growing a different range of organisms. Women with significant bacteriuria were more likely to have nocturia (OR 3.56, 95% CI 1.19-10.6, P=0.02), urgency (OR 6.66, 95% CI 1.47-30.06, P=0.01), bladder pain (OR 2.82, 95% CI 1-7.92, P=0.049), urgency incontinence (OR 2.92, 95% CI 1.02-8.36, P=0.046), nocturnal enuresis (OR 4.21, 95% CI 1.32-13.41, P=0.01). After adjustment for age, parity, symptomatic prolapse, menopausal status and history of mid-urethral sling urinary urgency, bladder pain, nocturia, and nocturnal enuresis remained significantly associated. Conclusions: Bacteriuria is associated with a range of LUTS including nocturia, urgency, and bladder pain supporting a role for bacterial colonization in the pathogenesis of OAB symptoms.

• 出版日期2015-6